Ming-Kuan Chyan Selected Research

Neoplasms (Cancer)

1/2023	Design and synthesis of astatinated benzothiazole compounds for their potential use in Targeted Alpha Therapy (TAT) strategies to treat Alzheimer's disease-associated amyloid plaques.
9/2022	Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo.
6/2011	Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.
7/2010	Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants.
1/2008	Streptavidin in antibody pretargeting. 5. chemical modification of recombinant streptavidin for labeling with the alpha-particle-emitting radionuclides 213Bi and 211At.
5/2004	Biotin reagents in antibody pretargeting. 6. Synthesis and in vivo evaluation of astatinated and radioiodinated aryl- and nido-carboranyl-biotin derivatives.
5/2002	A streptavidin-biotin binding system that minimizes blocking by endogenous biotin.

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Ming-Kuan Chyan Research Topics

Disease

7	Neoplasms (Cancer) 01/2023 - 05/2002
1	Amyloid Plaque 01/2023
1	Alzheimer Disease (Alzheimer's Disease) 01/2023
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023
1	Tauopathies 01/2023
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Blood-Borne Infections 11/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2018
1	Infertility (Sterility) 01/2018
1	Lymphoma (Lymphomas) 07/2010

Drug/Important Bio-Agent (IBA)

5	Radioisotopes (Radionuclides)IBA 09/2022 - 01/2008
4	Astatine-211IBA 09/2022 - 06/2011
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2010
3	Indicators and Reagents (Reagents)IBA 06/2011 - 05/2004
3	Biotin (Vitamin H)FDA Link 07/2010 - 05/2002
3	StreptavidinIBA 07/2010 - 05/2002
1	benzothiazoleIBA 01/2023
1	Amyloid (Amyloid Fibrils)IBA 01/2023
1	human FOLH1 proteinIBA 01/2021
1	Urea (Carbamide)FDA LinkGeneric 01/2021
1	Lysine (L-Lysine)FDA Link 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	AntibodiesIBA 01/2018
1	PyrogensIBA 01/2018
1	Monoclonal AntibodiesIBA 06/2011
1	GalactosamineIBA 07/2010
1	Single-Chain AntibodiesIBA 07/2010
1	DOTA-biotin (90Y-DOTA-biotin)IBA 07/2010

Therapy/Procedure

6	Therapeutics 01/2023 - 05/2002
1	Radiotherapy 09/2022
1	Cell Transplantation 01/2018
1	Radioimmunotherapy 05/2002